guide

HESI A2 Vocabulary study guide

How a word's meaning is decided by its sentence: the five context clues, the prefix-root-suffix system with a combining vowel, tables of the parts health care actually uses, irregular plurals, confusable pairs, and the general and health-care word lists this topic draws on.

What this topic actually asks of you

Vocabulary on this exam asks what a word means, and the work splits in two directions: reading a word from its context, and taking a long medical word apart into the pieces a health-care vocabulary is built from.

Elsevier lists vocabulary among the areas the HESI A2 covers. The publisher releases no national content specification — no item count, no clock, no cut score — so nothing on this page mirrors an official weighting, and nothing here claims to. What this page offers is a word-part system and a word list: the prefixes, roots and suffixes that build terms, and a plain-English list of the general and health-care words a passage is likely to use, each with its own example sentence.

The word parts follow the US National Library of Medicine's consumer guide to medical words; the definitions are standard meanings written for this course, with no dictionary text copied, and every example sentence is ours.

Study for the HESI A2 with us — free practice sets and topic guides

The nine ideas this page teaches

  1. Context clues — the six ways a sentence tells you what a word means.
  2. How a medical word is built — prefix, then root, then suffix, with a combining vowel when the suffix starts with a consonant.
  3. Prefixes of position, size and speed — the largest group, and the one that changes a word's direction.
  4. Roots — the body part or the substance the word is about.
  5. Suffixes — what is being done, and whether the word names a condition, a procedure or a specialist.
  6. Plurals of medical words — the endings that do not simply add an s.
  7. Confusable pairs — affect and effect, accept and except, and the rest of the pairs that look alike.
  8. Academic and health-care words — the general vocabulary of a passage about care, risk and outcome.
  9. Deriving an unknown word — what to do when a term is not on this page.

Context clues: six ways a sentence tells you

Clue What the sentence does Example
Context clue: definition a direct statement of the meaning, often in an appositive after a comma or a dash "The patient was afebrile — no fever at all — for three days."
Context clue: restatement a rewording in ordinary words nearby, set off by commas or a dash, that adds no new information "The wound was superficial, involving only the top layer of skin."
Context clue: contrast supplies the opposite, so the word must be its reverse "The first dose was benign in its effects, unlike the second, which caused a rash."
Context clue: example lists instances, and the word names the category "Vital signs such as pulse, blood pressure and temperature were recorded hourly."
Context clue: cause and effect the word's consequence is stated "Because the dressing was occlusive, it sealed the air out and the wound stayed moist."
Context clue: general sense the sentence's tone and subject narrow the meaning "The second reader would concur with the opinion, so the plan did not change."

The test for a context answer is a substitution: put your meaning back into the sentence and read it again. If the sentence still says something a nurse would say, the meaning fits. If it says something odd, the sense is wrong even when the word's dictionary meaning is right.

How a medical word is built

A medical term is assembled in a fixed order, and the order is the meaning.

prefix + root + suffix — as in bradycardia: brady- (slow) + card (heart) + -ia (condition), so a slow heart rate.

Piece What it contributes Where it sits Example
prefix position, number, size, speed, or a negation at the front tachy- in tachycardia, a fast heart rate
root the body part or substance the word is about in the middle gastr- in gastritis, inflammation of the stomach
combining vowel usually o, joining a root to a suffix that starts with a consonant between root and suffix o in gastroscopy, so the parts do not collide
suffix the condition, procedure, or kind of specialist at the end -itis in gastritis, meaning inflammation

Three rules make the system usable.

  • Read a long word from the suffix back to the prefix. The suffix says what kind of thing the word is, the root says where, and the prefix says how.
  • Keep the combining vowel only when the suffix begins with a consonant. gastr-o-scopy takes the o because -scopy starts with a consonant; gastr-itis drops it because -itis starts with a vowel.
  • Do not read a prefix as a word of its own. -ia at the end of bradycardia is the suffix that names a condition, not the prefix a- that means "without". The same letters, in different positions, are different pieces.

Prefixes: position, size, speed, number, negation

Learn the prefixes by what they do to a word's direction, not as a list of letters. Each one below is a piece of a word you will meet in a health-care passage.

Position

Prefix Meaning Word, and what it means
ante- before antepartum — the period before birth
pre- before preoperative — before a procedure
post- after postoperative — after a procedure
peri- around pericardium — the sac around the heart
circum- around circumcision — a cutting around
sub- under, below subcutaneous — under the skin
infra- below infrared — below red on the spectrum
supra- above suprapubic — above the pubic bone
epi- on, over epidermis — the layer over the dermis
endo- within endocrine — secreting within the body
intra- inside intravenous — inside a vein
inter- between intercostal — between the ribs
extra- outside extracellular — outside the cell
trans- across, through transdermal — through the skin
retro- backward, behind retroperitoneal — behind the peritoneum
ab- away from abduction — movement away from the midline
ad- toward adduction — movement toward the midline

Size, speed and amount

Prefix Meaning Word, and what it means
brady- slow bradycardia — a slow heart rate
tachy- fast tachypnea — fast breathing
macro- large macrophage — a large cell that engulfs debris
micro- small microcyte — a small red blood cell
mega- very large megacolon — an abnormally wide colon
hyper- above normal hypertension — high blood pressure
hypo- below normal hypotension — low blood pressure
oligo- few, scanty oliguria — scanty urine output
poly- many, much polyuria — excessive urine output
eu- normal, good eupnea — normal breathing
neo- new neonate — a newborn

Number

Prefix Meaning Word, and what it means
mono-, uni- one mononucleosis, unilateral — one side
bi-, di- two bilateral — both sides
tri- three tricuspid — a valve with three flaps
quadri- four quadriplegia — loss of function in all four limbs
hemi- half hemiplegia — loss of function on one side
semi- half semicircular — half a circle, as in the ear's canals

Negation and absence

Prefix Meaning Word, and what it means
a-, an- without afebrile — without fever; anemia — without sufficient blood
anti- against antibiotic — against bacteria
contra- against contraindication — a reason against a treatment
de- down, away from dehydration — loss of water
dis- apart, not dislocation — displacement of a joint
mal- bad, abnormal malnutrition — poor nutrition
dys- difficult, abnormal dyspnea — difficult breathing

Two prefixes are worth a warning because they look like ordinary words. Hyper- and hypo- differ by one letter and mean opposite things — a hyperglycemic patient is high, a hypoglycemic patient is low, and confusing them is a clinical error, not a vocabulary slip. Dys- means difficult or abnormal, not absent: dysuria is painful urination, anuria is none.

Roots: the body part inside the word

Root Means Word, and what it means
cardi- heart cardiology — the study of the heart
pulmon-, pneum- lung, air pulmonary — relating to the lungs; pneumonia — an infection of the lung
gastr- stomach gastrectomy — removal of the stomach
hepat- liver hepatomegaly — an enlarged liver
nephr- kidney nephritis — inflammation of a kidney
ren- kidney renal — relating to the kidney
cyst- bladder, sac cystoscopy — viewing inside the bladder
enter- intestine enteritis — inflammation of the intestine
col-, colon- colon colostomy — an opening into the colon
arthr- joint arthritis — inflammation of a joint
oste- bone osteoporosis — bone that has thinned and weakened
my-, myo- muscle myalgia — muscle pain
derm-, dermat- skin dermatitis — inflammation of the skin
neur- nerve neurology — the study of the nervous system
encephal- brain encephalitis — inflammation of the brain
cerebr- brain cerebral — relating to the cerebrum
hem-, hemat- blood hematocrit — the proportion of blood that is red cells
vas-, vascul- vessel vascular — relating to blood vessels
therm- heat thermometer — an instrument for measuring heat
glyc- sugar glycemia — the sugar level in the blood
lip- fat lipids — fats and fat-like substances
cutane- skin cutaneous — relating to the skin
cost- rib intercostal — between the ribs
thorac- chest thoracic — relating to the chest
abdomin- abdomen abdominal — relating to the abdomen
hist- tissue histology — the study of tissue

Roots come in two spellings more often than the table suggests, and both spellings mean the same thing: nephr- and ren- are both kidney, pneum- and pulmon- are both lung, encephal- and cerebr- are both brain. Either spelling in a word tells you the organ; the rest of the word tells you what is happening to it.

Suffixes: what is being done, and to what kind of word

The suffix tells you what kind of thing the word is — a condition, an inflammation, a procedure, a specialist, or a record. Read it first.

Conditions and processes

Suffix Means Word, and what it means
-itis inflammation gastritis — inflammation of the stomach
-osis a condition, often abnormal osteoporosis — a condition of thinned bone
-iasis a condition, often caused by something cholelithiasis — the presence of gallstones
-pathy disease neuropathy — disease of a nerve
-emia a condition of the blood anemia — a shortage of red cells or hemoglobin
-uria a condition of the urine hematuria — blood in the urine
-oma a tumor or swelling hematoma — a swelling of clotted blood
-megaly enlargement cardiomegaly — an enlarged heart
-plegia paralysis paraplegia — loss of function in the lower limbs
-pnea breathing dyspnea — difficult breathing
-rrhea flow, discharge diarrhea — a flow of loose stool
-spasm an involuntary contraction bronchospasm — a tightening of the airways
-stenosis narrowing arteriostenosis — a narrowing of an artery
-edema swelling from fluid lymphedema — swelling from lymph that cannot drain

Procedures, records and specialists

Suffix Means Word, and what it means
-scopy viewing with an instrument endoscopy — viewing the inside of a tract
-ectomy surgical removal appendectomy — removal of the appendix
-otomy a cutting into tracheotomy — a cutting into the windpipe
-ostomy a surgical opening colostomy — an opening from the colon to the surface
-plasty repair, reshaping angioplasty — repair of a blood vessel
-rrhaphy suturing herniorrhaphy — suturing a hernia
-centesis a puncture to draw fluid amniocentesis — sampling amniotic fluid
-gram a record or image electrocardiogram — a record of the heart's electrical activity
-graphy the process of recording radiography — imaging with radiation
-meter an instrument for measuring spirometer — an instrument that measures lung volumes
-logy the study of hematology — the study of blood
-logist a specialist in oncologist — a specialist in cancer care
-algia pain arthralgia — joint pain
-ic, -al, -ary relating to cardiac, renal, pulmonary — relating to the heart, kidney, lungs
-ous full of, having mucous — producing mucus

Two pairs are easy to mix and worth naming. -ectomy removes, -otomy cuts into, -ostomy makes a new opening that stays; the three words differ in what happens to the tissue afterwards. -gram is the record, -graph is the instrument that makes it, -graphy is the process — a cardiogram is the tracing, a cardiograph is the machine.

Plurals: the endings that do not take an s

Medical words keep the plural of the language they were borrowed from, so the plural is learned with the word itself. The pattern is regular once you know it.

Singular ending Plural ending Example
-a -ae vertebra → vertebrae
-us -i bronchus → bronchi; stimulus → stimuli
-um -a bacterium → bacteria; atrium → atria
-on -a criterion → criteria
-is -es diagnosis → diagnoses; crisis → crises
-ix, -ex -ices appendix → appendices; cortex → cortices

The rule of thumb: if the word ends in -is, the plural is -es and the vowel changes; if it ends in -um, the plural is -a. The plural of analysis is analyses, not analysises, and the plural of datum is data, which is why "the data show" is correct in careful writing even though "the data shows" is common in speech.

Confusable pairs: the words that cost the easiest point

These are pairs a question can test without any medical content at all, and a passage can turn on one of them. The right-hand column is the test that separates them; Grammar takes the usage rules further.

Pair The distinction The test
affect / effect affect is usually a verb (to influence); effect is usually a noun (a result) if you can put "the" in front of it, it is effect
advice / advise advice is the noun; advise is the verb "she gave me ___" takes the noun
breath / breathe breath is the noun; breathe is the verb "to ___" takes the verb
accept / except accept means to receive; except means to leave out "everyone ___ one" needs except
conscious / conscience conscious means awake or aware; conscience is the sense of right and wrong "the patient was ___" (awake) takes conscious; "a guilty ___" takes conscience
complement / compliment complement completes; compliment praises a full set complements; a nice remark compliments
discreet / discrete discreet means tactful; discrete means separate separate items are discrete
elicit / illicit elicit means to draw out; illicit means unlawful a response is elicited
eminent / imminent eminent means distinguished; imminent means about to happen a risk that is about to happen is imminent
ensure / insure ensure means to make certain; insure means to cover by insurance "___ that the door is locked" takes ensure
loose / lose loose means not tight; lose means to no longer have "did not ___ the chart" takes lose
precede / proceed precede means to come before; proceed means to go on the step that comes first precedes
principal / principle principal means main, or a leading person; principle is a rule or belief "the ___ reason" takes principal
stationary / stationery stationary means not moving; stationery is paper and envelopes a patient who does not move is stationary
than / then than compares; then marks time a comparison takes than
their / there / they're possession / place / "they are" substitute "they are" and see if the sentence survives

The general words a passage uses

These are the words that carry a passage's argument rather than its subject. Each is defined in one line and used in a sentence this course wrote.

Word Means In a sentence
acute sharp, severe, or of short duration The acute pain subsided within an hour of the dose.
adequate enough for the purpose An adequate supply of gloves was kept at every station.
adverse harmful, unfavorable The adverse reaction was reported the same day.
ambiguous open to more than one reading The order was ambiguous, so the nurse repeated it back.
chronic long-lasting, persisting Chronic conditions need review at every visit.
compensate to make up for a loss or a defect The body compensates for the blood loss by narrowing vessels.
comply to act in line with a rule or request The unit complied with the new hand-hygiene policy.
concur to agree The second clinician would concur with the diagnosis once the scan was read.
consequence a result that follows A consequence of the delay was a longer stay.
consistent the same each time, without contradiction Her notes were consistent across all three visits.
deteriorate to become worse The patient's breathing deteriorated overnight.
distinguish to tell one thing from another Distinguish a faint pulse from no pulse before starting compressions.
exacerbate to make worse Cold air exacerbates the cough.
facilitate to make easier A checklist facilitates the handover between shifts.
imply to suggest without stating The note implies the dressing was changed, but does not say so.
infer to conclude from evidence From the chart you can infer that the dose was doubled.
minimal the least possible in the circumstances Movement was kept to a minimal level.
monitor to watch over time Monitor the site for redness every four hours.
predispose to make more likely in advance A long stay predisposes a patient to weakness.
prevalent common in a place or group The condition is more prevalent in older adults.
prohibit to forbid The policy prohibits reusing a single-use needle.
reluctant unwilling The patient was reluctant to describe the pain.
residual what remains A residual cough persisted for a week.
subsequent coming after A subsequent test confirmed the first result.
sufficient enough Sufficient fluid intake was recorded on the chart.
symptomatic showing signs of a condition She remained symptomatic for two days.
tolerate to endure without serious harm He tolerated the medication without nausea.
unremarkable within normal limits The abdominal exam was unremarkable.
vital necessary to life, or essential Vital signs were recorded on admission.
withhold to hold back deliberately The dose was withheld until the blood pressure was checked.

The health-care terms a passage assumes you know

These are terms a reading passage may use without defining, because the writer expects a health-care student to have met them. The definition is the plain meaning; the sentence is ours.

Term Means In a sentence
afebrile without fever The child was afebrile by the second morning.
ambulatory able to walk; not bed-bound The patient was ambulatory by the third day.
bolus a single dose given at once; also a mass of chewed food ready to swallow The bolus was given over two minutes.
contusion a bruise A contusion spread across the forearm.
cyanosis a blue-gray tint from low oxygen Cyanosis at the lips prompted an immediate oxygen check.
diaphoresis heavy sweating Diaphoresis accompanied the drop in blood pressure.
distention swelling from internal pressure Abdominal distention was noted after the meal.
dysphagia difficulty swallowing Dysphagia put the patient on a soft diet.
emesis vomiting Emesis followed the second dose.
febrile having a fever The patient remained febrile through the night.
flatus gas passed from the bowel Passing flatus was the sign the bowel had resumed.
hematemesis vomiting blood Hematemesis was reported to the clinician at once.
idiopathic of unknown cause The diagnosis was idiopathic, meaning no cause was found.
incontinence loss of control over urine or stool Incontinence was recorded at each check.
intubate to place a tube in the airway The team chose to intubate before the transfer.
laceration a cut The laceration was cleaned and closed.
lethargy unusual drowsiness and low energy Lethargy in an older patient is a warning sign.
malaise a general feeling of being unwell Malaise was the only symptom reported.
necrosis death of tissue Necrosis at the wound edge required review.
orthopnea breathlessness when lying flat Orthopnea led her to sleep propped up.
pallor unusual paleness Pallor and cool skin suggested poor circulation.
pruritus itching Pruritus spread across the chest and back.
purulent containing pus The drainage turned purulent by day four.
rales crackling sounds heard in the lungs Rales were heard at both bases.
syncope fainting Syncope on standing was reported twice.
vertigo a sense of spinning Vertigo made the walk to the bathroom unsafe.
void to pass urine The patient voided within an hour of surgery.

Deriving a word that is not on this page

Most terms a passage uses are not in any list, including this one. Four steps will get you a working meaning.

  1. Take the suffix first. It tells you what kind of word this is: a condition (-itis, -osis), a procedure (-ectomy, -scopy), a specialist (-logist), or a description (-ic, -al).
  2. Find the root. It names the part or the substance. Where two roots appear, the first usually names a part and the second the thing done or found there, as in gastr-o-enter-itis — stomach and intestine, both inflamed.
  3. Read the prefix last. It changes direction or degree: sub- under, hyper- above, brady- slow, poly- many.
  4. Check the whole against the sentence. A derived meaning that contradicts the sentence is wrong, and the sentence wins. Context is the final test, not the parts.

Worked example: pericardiocentesis. Suffix -centesis — a puncture to draw fluid. Root cardi — heart. Prefix peri- — around. So: a puncture into the sac around the heart to draw off fluid. A sentence saying "the fluid was sent for culture" confirms the reading; a sentence saying the patient was given a tablet would not, and the sentence would overrule the parts.

The list, in one place

Every word part this page teaches, alphabetized, with no example word and no explanation beside it. The point of the plain version is that it can be drilled: cover the middle column, read the part, say what it does, and uncover. A part you can say cold is a part you will read correctly inside a word you have never seen; a part you can only recognize in the example word it was taught with has not been learned yet.

96 parts is not a memorization project to finish in one sitting. Three passes of ten minutes, a day apart, with the third pass done from the part alone, moves more than an hour of re-reading the tables above.

The parts are not the whole vocabulary section: a 150-word list of the words this course teaches covers the general, health-care and science terms that are used rather than dissected.

Word part Means Kind
a-, an- without prefixes
ab- away from prefixes
abdomin- abdomen roots
ad- toward prefixes
-algia pain suffixes
ante- before prefixes
anti- against prefixes
arthr- joint roots
bi-, di- two prefixes
brady- slow prefixes
cardi- heart roots
-centesis a puncture to draw fluid suffixes
cerebr- brain roots
circum- around prefixes
col-, colon- colon roots
contra- against prefixes
cost- rib roots
cutane- skin roots
cyst- bladder, sac roots
de- down, away from prefixes
derm-, dermat- skin roots
dis- apart, not prefixes
dys- difficult, abnormal prefixes
-ectomy surgical removal suffixes
-edema swelling from fluid suffixes
-emia a condition of the blood suffixes
encephal- brain roots
endo- within prefixes
enter- intestine roots
epi- on, over prefixes
eu- normal, good prefixes
extra- outside prefixes
gastr- stomach roots
glyc- sugar roots
-gram a record or image suffixes
-graphy the process of recording suffixes
hem-, hemat- blood roots
hemi- half prefixes
hepat- liver roots
hist- tissue roots
hyper- above normal prefixes
hypo- below normal prefixes
-iasis a condition, often caused by something suffixes
-ic, -al, -ary relating to suffixes
infra- below prefixes
inter- between prefixes
intra- inside prefixes
-itis inflammation suffixes
lip- fat roots
-logist a specialist in suffixes
-logy the study of suffixes
macro- large prefixes
mal- bad, abnormal prefixes
mega- very large prefixes
-megaly enlargement suffixes
-meter an instrument for measuring suffixes
micro- small prefixes
mono-, uni- one prefixes
my-, myo- muscle roots
neo- new prefixes
nephr- kidney roots
neur- nerve roots
oligo- few, scanty prefixes
-oma a tumor or swelling suffixes
-osis a condition, often abnormal suffixes
oste- bone roots
-ostomy a surgical opening suffixes
-otomy a cutting into suffixes
-ous full of, having suffixes
-pathy disease suffixes
peri- around prefixes
-plasty repair, reshaping suffixes
-plegia paralysis suffixes
-pnea breathing suffixes
poly- many, much prefixes
post- after prefixes
pre- before prefixes
pulmon-, pneum- lung, air roots
quadri- four prefixes
ren- kidney roots
retro- backward, behind prefixes
-rrhaphy suturing suffixes
-rrhea flow, discharge suffixes
-scopy viewing with an instrument suffixes
semi- half prefixes
-spasm an involuntary contraction suffixes
-stenosis narrowing suffixes
sub- under, below prefixes
supra- above prefixes
tachy- fast prefixes
therm- heat roots
thorac- chest roots
trans- across, through prefixes
tri- three prefixes
-uria a condition of the urine suffixes
vas-, vascul- vessel roots

Sort order is alphabetical on the part itself, so -algia sits among the a's regardless of the dash and -ectomy among the e's. Where two spellings mean the same thing — nephr- and ren-, mono- and uni- — they are one line, because the exam will not ask you which spelling is more correct.

The traps, collected

The trap What it looks like The fix
Common mistake: picking the most familiar meaning Wrong: practice read as "rehearse" in a clinical passage substitute the choice back into the sentence
Common mistake: ignoring the part of speech Wrong: effect chosen where the sentence needs a verb decide which word class the blank needs first
Common mistake: reading half the prefix Wrong: hypo- read as hyper- read the prefix to its last letter; they mean opposites
Common mistake: taking a word part out of order Wrong: the -ia of bradycardia read as the a- of apnea, so the last piece is taken for the first and the root is skipped read suffix back to prefix: brady- (slow) + cardi (heart) + -ia (condition)
Common mistake: trusting a near-synonym a choice that is close but shifts the degree ask whether the sentence says "a lot" or "a little"
Common mistake: assuming one spelling per root Wrong: nephr- missed because the word says renal learn the root pairs, not single spellings
Common mistake: dropping the combining vowel wrongly Wrong: gastritis read as gastr-o-itis the vowel is dropped before a vowel-initial suffix
Common mistake: choosing a true statement that does not answer the choice defines the word but not its sense here answer the sentence's question, not the dictionary's

How to practice this

  • Build ten words a day from parts. Take a suffix from this page and a root, add a prefix, and write the meaning before you look it up. Ten a day is seventy a week, and the same parts come round again.
  • Keep a context notebook. When a word stops you, write the sentence down, not just the word. The sentence is what you will recognize next time.
  • Drill the pairs aloud. Affect and effect are separated by a frame rather than a definition: say "the effect" and "to affect" until the frame is automatic.
  • Read one label a day. A medication label or an instruction sheet gives you real sentences with real terms, and the same terms appear on the next label.
  • Test yourself backwards. Given a meaning, produce the word. Recognition is what a passage question asks for, but producing the word is what proves you know it.

Where to go next

  • The subject's own page — Vocabulary lists what is published for this subject, including its guide and its practice set as they land.
  • The sentences these words sit in — Grammar: agreement, punctuation and the errors that make a clear word ambiguous.
  • Reading a passage that uses them — Reading Comprehension: the method for finding the one line that answers a question.
  • The science behind the roots — Biology and Chemistry: the body systems and the substances these terms name.

Sources. The prefix, root and suffix lists follow the US National Library of Medicine's consumer guidance on understanding medical words (medlineplus.gov), US federal government material that is not subject to copyright in the United States; the word parts and their meanings are standard medical terminology and are given here in our own words. The plural patterns follow the same guidance and standard English usage. Every definition, example sentence and table on this page was written for this course; no dictionary or glossary text is reproduced. The publisher's own account of the areas the exam covers is quoted from its HESI A2 page. Accessed 2026-10-27.

HESI A2 is a trademark of Elsevier Inc. Elk Ridge Academy is an independent study resource and is not affiliated with, endorsed by, or sponsored by Elsevier Inc. Exam names are used descriptively only.

Source: MedlinePlus (US National Library of Medicine) consumer guidance on understanding medical words for the prefix, root and suffix system and for plural patterns. US federal government material, not subject to copyright in the United States. Every definition, example sentence and table is written for this course (MedlinePlus accessed 2026-10-27; the Elsevier HESI A2 page accessed 2026-10-23)

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