Glossary

hypodermis

The hypodermis is the fatty layer under the dermis — subcutaneous tissue that insulates, cushions, stores energy and anchors the skin.

Also written: subcutaneous tissue, subcutaneous

The hypodermis is the layer beneath the dermis, also called subcutaneous tissue. It is mostly fat cells held in connective tissue, and it does four jobs: it insulates, it cushions the structures above and below it from pressure, it stores energy, and it anchors the skin to the muscle and bone underneath so the skin does not slide. It carries the larger vessels and nerves on their way to the skin. Its thickness varies by region and by person — the abdomen and hips carry more than the back of the hand — which is why an injection is placed in it where the tissue is thick enough to take the volume and the drug is meant to be absorbed slowly. Because it is fat, it is also where the body's long-term energy reserve sits.

Source: The anatomy and physiology guide in this course, whose organ and tissue descriptions follow the US National Cancer Institute's SEER Training Modules and MedlinePlus consumer health pages. Both are US federal government material, not subject to copyright in the United States. The definition above is written for this course in our own words. (SEER Training Modules accessed 2026-10-26; definition written 2026-10-27)

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