guide

TEAS Human anatomy and physiology study guide

The ATI TEAS Anatomy and physiology sub-content area, system by system in ATI's own order — orientation and directional terms, the respiratory system and the path air takes, the heart, the blood vessels, the blood and the heart's conduction path, and the digestive tube with its accessory organs — each system's parts in a reference table, its mechanism as a path, and one worked example per procedure, plus the traps these items set and three strategies for a pathway question.

What this topic actually asks of you

Human anatomy and physiology is one of the twelve sub-content areas of the ATI TEAS, and it is the largest sub-content area in Science — and one of the two largest on the whole exam, tied with numbers and algebra: ATI publishes it as 12% of the exam and 18 of the 44 scored science questions, the same 18 that numbers and algebra carries in math. The whole Science section is 50 items (44 scored, 6 unscored) and is timed separately — 60 minutes.

Three things follow, and they shape how to study it.

  • It is twelve short subjects, not one big one. ATI's objective list walks the body system by system. Each system has its parts (anatomy: what is there, and where) and its one working mechanism (physiology: how the parts make the job happen — the path air takes, the path blood takes, the path food takes). Learn a system as a list of parts plus one path, and the questions stop being a memory test.
  • Most of the points are recall; the mechanism items are where items get harder. Naming the chamber that pumps blood to the body is one fact. Putting the stations of a pathway in order, or saying what happens when one station is blocked, is several facts used together — that is where the exam separates a learner who memorized a diagram from one who understood it.
  • One arithmetic family, and it is small. Cardiac output is heart rate × stroke volume. That is the whole calculation in this topic; everything else is words. The words are the trap: ureter and urethra, bronchus and bronchiole, afferent and efferent, sympathetic and parasympathetic, innate and adaptive.

Our practice items are single-answer and text-only. The real ATI TEAS also uses other item types: ATI's own content outline lists multiple-choice, multiple-select, fill-in-the-blank numeric, hot spot and ordered-response items. Elk Ridge Academy's practice items are single-answer only, and they carry no pictures or diagrams — a pathway is written as text — so treat the method, not any one format, as the thing you are drilling.

ATI's anatomy-and-physiology objectives. ATI's Content Outline names what this topic measures, and every practice item below maps to one of them: S.1.1 the general orientation of human anatomy · S.1.2 the respiratory system · S.1.3 the cardiovascular system · S.1.4 the digestive system · S.1.5 the nervous system · S.1.6 the muscular system · S.1.7 the male and female reproductive system · S.1.8 the integumentary system · S.1.9 the endocrine system · S.1.10 the urinary system · S.1.11 the immune system · S.1.12 the skeletal system.

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How to read this guide

This guide takes ATI's objectives in ATI's order: orientation first, because every other section uses its words ("the superior vena cava", "a medial structure", "a cut across the thorax"), then the systems one by one. Each section has the same three things:

  1. The parts, in a reference table — what each part is and what it does.
  2. The mechanism, as a path you can say out loud (air, blood, food, urine, a nerve impulse).
  3. A worked example, showing how one question in that section is answered.

One thing this guide does not reteach: the levels of organization. Cell → tissue → organ → organ system is science biology's material (cell organization); here it appears once, as the sentence that explains why an organ system is "a group of organs with a shared job". If tissues and organs are the missing piece for you, read the Biology guide first.

Every table here restates OpenStax Anatomy and Physiology, 2nd edition (2022, CC BY 4.0, openstax.org — chapters 1, 5–6, 10–11 and 17–28) in our own words, with our own examples; nothing is copied and no figure is reproduced. The foot of this page carries the full source list.

S.1.1 — Orientation: naming where a structure is

Before a single organ, learn the vocabulary of position. Every later question is easier when "superior" and "medial" are automatic.

Anatomical position is the reference point. A body in the anatomical position is standing upright, face forward, feet flat and slightly apart, and arms at the sides with the palms facing forward and the thumbs pointing away from the body. Every directional word below assumes that position: in it the palm faces anteriorly, even if a hand is turned palm-back.

Directional terms come in pairs. Learn them as opposites, and remember that they describe the body's own directions, not the page: "medial" means toward the body's midline even when the body is drawn sideways.

Table 1 — The directional terms, as pairs.

Question Its opposite What it means
What is the opposite of Superior (cranial)? Inferior (caudal) closer to the head / closer to the feet — "the heart is superior to the stomach"
What is the opposite of Anterior (ventral)? Posterior (dorsal) toward the front of the body / toward the back — "the sternum is anterior to the heart"
What is the opposite of Medial? Lateral toward the midline / away from the midline — "the thumb is lateral to the little finger"
What is the opposite of Proximal? Distal closer to where the limb joins the trunk / farther from it — "the elbow is proximal to the wrist"
What is the opposite of Superficial? Deep closer to the surface / farther in — "the skin is superficial to the muscle"

Three planes cut the body. A plane is a flat surface the body is viewed or cut through. The name says which way the cut runs; that is the whole question — which plane is named?

Table 2 — The body planes and the body cavities.

Question What it divides, or what it holds
Where does the Sagittal plane divide the body? divides the body into left and right parts; a cut down the middle (midsagittal) makes two equal halves
Where does the Frontal (coronal) plane divide the body? divides the body into front and back parts
Where does the Transverse plane divide the body? divides the body into upper and lower parts — a cross-section through the trunk
What does the Dorsal cavity hold? at the back of the body; holds the cranial cavity (the brain) and the spinal cavity (the spinal cord)
What does the Ventral cavity hold? at the front of the body; holds the thoracic cavity (heart, lungs) and the abdominopelvic cavity
What does the Thoracic cavity hold? the chest; the heart and lungs, separated from the abdomen below by the diaphragm
What does the Abdominopelvic cavity hold? the abdominal part (stomach, intestines, liver) and the pelvic part (bladder, reproductive organs)
What are the Abdominopelvic quadrants? four regions used to locate a structure — upper-right, upper-left, lower-right, lower-left — named for the body's own right and left, not the viewer's, with the lines crossing at the umbilicus

1. Orientation terms — which directional word fits

Which directional term describes the relationship of the elbow to the wrist on the same arm?

  1. Both points are on the same limb, so the pair that only moves toward the head or the feet — superior/inferior — says nothing about them.
  2. The elbow is closer to the trunk than the wrist; the wrist is farther down the limb.
  3. Closer to where the limb joins the trunk is proximal, so the elbow is proximal to the wrist, and the wrist is distal to the elbow.

The trap: reading proximal/distal as "up and down" instead of "along the limb". Up and down is superior/inferior; along a limb is proximal/distal.

2. Body planes — name the cut

A cut divides the body into an upper part and a lower part. Which plane is it?

  1. Read what the cut separates: left from right is sagittal; front from back is frontal.
  2. This cut separates upper from lower — neither of those.
  3. A plane that divides the body into upper and lower parts is a transverse plane (a cross-section) — the plane a body scan slices the trunk in.

The trap: "frontal" sounds like the front of the body, but the frontal plane divides front from back. The name describes the cut, not the surface you end up looking at.

3. Body cavities — which cavity holds what

The heart and lungs sit in which body cavity?

  1. The body has two main cavities: dorsal (the brain and the spinal cord) and ventral (everything at the front of the trunk).
  2. The heart and lungs sit at the front, not the back, so the dorsal cavity is out.
  3. The front-of-trunk cavity is the ventral cavity, and the heart and lungs occupy its upper division, the thoracic cavity, separated from the abdomen below by the diaphragm.

The trap: putting the heart and lungs in the dorsal cavity — they are posterior to the sternum, but the dorsal cavity is the name of one compartment, the one holding the brain and spinal cord. Being posterior to the sternum does not put an organ in the dorsal cavity, and dorsal as a direction does mean posterior.

S.1.2 — The respiratory system

The respiratory system does two jobs at once: it moves air and it exchanges gases. The parts are one tube that branches over and over until it ends in millions of tiny sacs, each wrapped in capillaries.

The parts, from the outside in. Air is warmed, moistened and filtered as it passes the nose. The pharynx is the throat shared with food; the larynx is the voice box, where the vocal cords sit and the epiglottis keeps food out of the airway. The trachea (windpipe) carries air to the chest, held open by C-shaped cartilage rings — and it sits anterior to the esophagus, so food passes behind the airway. The trachea divides into the bronchi (one per lung), which divide again into bronchioles, which end in the alveoli — thin-walled air sacs where gas exchange happens.

Table 3 — The parts of the respiratory system.

Question What it does
What is the job of the Nose and nasal cavity? warms, moistens and filters the air; the first station of the pathway
What is the job of the Pharynx (throat)? a passage shared by air and food; air passes through it on its way to the larynx
What is the job of the Larynx (voice box)? holds the vocal cords and the epiglottis, which closes over the airway when you swallow
What is the job of the Trachea (windpipe)? carries air to the chest; held open by C-shaped cartilage rings and sits in front of the esophagus
What is the job of the Bronchi? the two branches the trachea divides into, one entering each lung
What is the job of the Bronchioles? the smaller airways the bronchi branch into inside the lungs
What is the job of the Lungs? the two organs that hold the airways and the alveoli; the right lung has three lobes, the left has two
What is the job of the Alveoli? the thin-walled air sacs where oxygen and carbon dioxide are exchanged; each is wrapped in capillaries
What is the job of the Diaphragm? the dome-shaped muscle under the lungs that drives breathing

Table 4 — The path air takes, nose to blood.

Question What happens there
What happens at the Nose (nasal cavity) station on the air's path? warmed, moistened, filtered
What happens at the Pharynx station on the air's path? passes the throat, behind the mouth
What happens at the Larynx station on the air's path? past the vocal cords, guarded by the epiglottis
What happens at the Trachea station on the air's path? down the windpipe, in front of the esophagus
What happens at the Bronchi station on the air's path? into one lung each
What happens at the Bronchioles station on the air's path? branching inside the lung
What happens at the Alveoli station on the air's path? gas exchange: oxygen into the blood, carbon dioxide out

Breathing is a pressure story. The diaphragm contracts and flattens while the ribs lift: the chest gets bigger, the pressure inside falls, and air flows in. Breathing out is mostly passive — the diaphragm relaxes back into its dome, the chest gets smaller, pressure rises above the outside pressure, and air leaves. Nothing has to be pumped out.

Table 5 — Breathing: inhale and exhale.

Question What the muscles do What happens to the chest and the air
During Inspiration (inhale), what do the muscles do? the diaphragm contracts and flattens; the ribs lift chest volume increases, pressure inside the chest falls below the outside pressure, so air flows in
During Expiration (exhale), what do the muscles do? the diaphragm relaxes back into its dome; the ribs fall chest volume decreases, pressure inside rises above the outside pressure, so air flows out — mostly passive

Gas exchange is diffusion, one direction per gas. In the alveolus, oxygen is high and in the arriving blood it is low, so oxygen moves from the air into the blood; carbon dioxide is high in the blood and low in the air, so it moves from the blood into the air you breathe out. Most oxygen then rides on hemoglobin inside red blood cells; most carbon dioxide travels in the plasma as bicarbonate, with a little riding on hemoglobin too.

Table 6 — Gas exchange, and how each gas travels.

Question The one fact to know
Where does gas exchange happen? across the wall of the alveolus into the capillary wrapped around it
Which direction does oxygen move? air → blood: the alveolus holds more oxygen than the arriving blood
Which direction does carbon dioxide move? blood → air: the blood holds more carbon dioxide than the air in the alveolus
How does oxygen travel in the blood? bound to hemoglobin in red blood cells
How does carbon dioxide travel in the blood? mostly as bicarbonate in the plasma, with some bound to hemoglobin
Why does the gas exchange work? the alveolar wall and the capillary wall are each one cell thick, so the gases have almost nothing to cross

4. Respiratory organs — the part that keeps the airway open

Which structure keeps the trachea from collapsing as air moves through it?

  1. The airway must stay open while air moves in and out under changing pressure.
  2. The trachea's wall carries C-shaped rings of cartilage — firm, but open at the back, where the esophagus can bulge as food passes.
  3. So the structure holding the trachea open is its cartilage rings — the same job cartilage does in the nose and in the bronchi.

The trap: treating the rings' shape ("C-shaped") as a separate structure, or swapping the trachea's position with the esophagus behind it.

5. The air pathway — put the stations in order

Which list is the correct path of air from the outside to the exchange surface?

  1. Air enters at the nose, and the throat and voice box follow: pharynx, then larynx.
  2. From the larynx the air goes down the trachea, which branches into the bronchi, and those branch into the bronchioles inside the lung.
  3. The smallest airways end in the alveoli, where the gas exchange happens — so the order is nose → pharynx → larynx → trachea → bronchi → bronchioles → alveoli.

The trap: putting the bronchioles before the bronchi. The branches get smaller as you go in; a bronchiole is the small end of a bronchus.

6. Breathing mechanics — what the diaphragm does

What happens to the diaphragm during inspiration?

  1. Inspiration means air is flowing in, which needs the space inside the chest to get bigger.
  2. The diaphragm contracts, and a contracted diaphragm flattens downward.
  3. A flattened diaphragm increases the volume of the thoracic cavity, which lowers the pressure inside the chest below the outside pressure — so air flows in.

The trap: reversing the direction. Contracting and flattening brings air in; relaxing back into a dome pushes air out.

7. Gas exchange — which way each gas goes

At the alveolus, which way does carbon dioxide move?

  1. The alveolus is the air side; the capillary wrapped around it is the blood side.
  2. The body's cells produce carbon dioxide, so the arriving blood carries more of it than the air in the alveolus holds.
  3. A gas diffuses from where it is more concentrated to where it is less, so carbon dioxide moves from the blood into the alveolus — and leaves the body on the next exhale.

The trap: swapping the two gases' directions. Oxygen goes into the blood and carbon dioxide leaves it; both move toward the lower concentration, which is why neither gas needs a pump.

S.1.3 — The cardiovascular system

This is the topic's biggest system, and the one an exam likes best, because it has one path to learn and a handful of structures that are easy to confuse. Learn the path once and most of the section answers itself.

The heart is two pumps side by side. The right side receives oxygen-poor blood from the body and pumps it to the lungs; the left side receives oxygen-rich blood from the lungs and pumps it to the whole body. A wall called the septum separates the two sides, so oxygen-poor and oxygen-rich blood do not mix. Each side has an upper chamber (atrium, which receives) and a lower chamber (ventricle, which pumps) — and because the left ventricle pushes blood through the entire body, its wall is the thickest of the four chambers.

Valves keep the flow one-way. A valve sits between each atrium and ventricle (tricuspid on the right, bicuspid or mitral on the left), and one sits at each exit into a great vessel (pulmonary semilunar and aortic semilunar). A valve's job is always the same: it stops blood flowing backwards, and when it closes is the part to keep straight — the AV valves (tricuspid and bicuspid) close when the ventricles contract, and the semilunar valves close when the ventricles relax.

Table 7 — The heart: chambers, valves and vessels.

Question What it does
What is the job of the Right atrium? receives oxygen-poor blood returning from the body through the venae cavae
What is the job of the Right ventricle? pumps oxygen-poor blood to the lungs through the pulmonary artery
What is the job of the Left atrium? receives oxygen-rich blood returning from the lungs through the pulmonary veins
What is the job of the Left ventricle? pumps oxygen-rich blood to the whole body through the aorta; the thickest-walled chamber
What is the job of the Tricuspid valve? between the right atrium and the right ventricle; stops backflow into the atrium
What is the job of the Bicuspid (mitral) valve? between the left atrium and the left ventricle; stops backflow into the atrium
What is the job of the Pulmonary semilunar valve? at the exit of the right ventricle, where blood leaves for the lungs
What is the job of the Aortic semilunar valve? at the exit of the left ventricle, where blood leaves for the body
What is the job of the Septum? the wall between the right and left sides; keeps oxygen-poor and oxygen-rich blood apart
What is the job of the Pericardium? the protective sac around the heart

Table 8 — The path blood takes through the heart, the lungs and the body.

Question The station
Where does blood enter the heart from the body? right atrium — blood returns from the body through the venae cavae
After the right atrium, where does the blood go next? through the tricuspid valve into the right ventricle
After the right ventricle, where does the blood go next? through the pulmonary semilunar valve into the pulmonary artery, to the lungs (oxygen in, carbon dioxide out)
After the lungs, where does the blood go next? back through the pulmonary veins into the left atrium
After the left atrium, where does the blood go next? through the bicuspid valve into the left ventricle
After the left ventricle, where does the blood go next? through the aortic semilunar valve into the aorta, and out to the body
After the body, where does the blood come back to? the blood returns through the venae cavae to the right atrium, and the circuit repeats

The heart has its own electrical path, which is why it beats without your deciding to beat it. The signal starts in a patch of specialized cells in the right atrium and travels down and out; that order is why the atria contract first and the ventricles second.

Table 9 — The heart's own electrical path (conduction).

Question Station What it does
Where does each heartbeat start? SA node (sinoatrial node) the pacemaker, in the wall of the right atrium; it starts each heartbeat
After the SA node, where does the signal go? AV node (atrioventricular node) the relay at the boundary between the atria and the ventricles; it delays the signal so the atria finish emptying first
After the AV node, where does the signal go? AV bundle (bundle of His) carries the signal from the AV node down into the wall between the ventricles
After the AV bundle, what carries the signal on? bundle branches carry the signal on down the wall between the ventricles
After the bundle branches, what spreads the signal through the ventricle walls? Purkinje fibers spread the signal through the ventricle walls, so the ventricles squeeze from the bottom up

Blood vessels come in three kinds, and one question — which direction is the blood going? — decides between them. Arteries carry blood away from the heart (under the highest pressure, so they have thick muscular walls and no valves); veins carry blood toward the heart (under the lowest pressure, so they have thinner walls and valves that stop the blood sliding back); capillaries are one cell thick, which is what lets exchange happen.

Table 10 — Blood vessels compared.

Question Artery Vein Capillary
Which way does blood flow in an artery? away from the heart toward the heart between the two, inside the tissues
What is the wall of an artery like? thick, muscular and elastic thinner, less muscle one cell thick
Does an artery have valves? none yes — they stop backflow none
What is the pressure in an artery like? highest lowest lower than in arteries, higher than in veins
What does an artery do? carries blood out to the body carries blood back to the heart the site where substances are exchanged with the tissues

Blood is tissue, not just liquid. Slightly over half of it is plasma — the liquid that carries dissolved substances, including carbon dioxide as bicarbonate. The rest is cells and cell fragments: red blood cells (which carry oxygen on hemoglobin), white blood cells (which defend the body) and platelets (which help it clot). This section names what each part does, not how many of each — cell counts are a lab test, not an entrance-exam fact.

Table 11 — The parts of blood.

Question What it carries, or what it does
What does Plasma carry, or do? the liquid part: water, proteins (including the clotting proteins), nutrients, hormones and wastes, and carbon dioxide as bicarbonate
What do red blood cells carry, or do? carry oxygen, bound to hemoglobin; they have no nucleus
What do white blood cells carry, or do? defend the body against pathogens
What do platelets carry, or do? cell fragments that help the blood to clot

The cardiac cycle is one beat, in two halves. In diastole the chambers relax and fill; in systole they contract and push the blood out. Cardiac output is the volume the heart pumps in a minute, and it is the one calculation in this topic: heart rate × stroke volume.

Table 12 — The cardiac cycle, and cardiac output.

Question What it means
What does Diastole mean? the chambers relax and fill with blood
What does Systole mean? the chambers contract and push blood out
What does Heart rate mean? the number of heartbeats in one minute
What does Stroke volume mean? the volume one ventricle ejects in one beat
What does Cardiac output mean? heart rate × stroke volume — the volume pumped in a minute

8. Heart structures — which chamber does which job

Which chamber of the heart pumps oxygen-rich blood to the whole body?

  1. Trace the blood: the body's blood returns oxygen-poor to the right side, so the right atrium and right ventricle cannot be the answer.
  2. The left side receives the oxygen-rich blood coming back from the lungs, into the left atrium first.
  3. The chamber that pumps from there is the left ventricle — and it is the thickest-walled chamber precisely because its blood goes everywhere.

The trap: choosing the left atrium (which receives oxygen-rich blood) instead of the left ventricle (which pumps it). Receiving and pumping are the two jobs the four chambers split between them.

9. The blood path — put the stations in order

Which list is the correct path of blood through the heart, starting from the right atrium?

  1. Blood enters the right atrium from the body, and the first valve it crosses is the tricuspid, into the right ventricle.
  2. From the right ventricle the blood leaves through the pulmonary semilunar valve into the pulmonary artery, and goes to the lungs to pick up oxygen.
  3. It returns through the pulmonary veins to the left atrium, crosses the bicuspid valve into the left ventricle, leaves through the aortic semilunar valve into the aorta, and goes out to the body — so the order is right atrium → right ventricle → pulmonary artery → lungs → pulmonary veins → left atrium → left ventricle → aorta.

The trap: sending the blood from the right ventricle straight to the aorta, or from the left ventricle to the lungs. The right side goes to the lungs and the left side goes to the body — never the reverse.

10. Blood vessels — artery or vein

Which feature belongs to veins rather than arteries?

  1. Both carry blood, so the useful question is which way and under what pressure: arteries leave the heart at high pressure, veins come back at low pressure.
  2. A vessel that carries blood back at low pressure needs something to stop the blood sliding backwards, because nothing is pushing it.
  3. That something is valves, which are found in veins — arteries have none, and instead carry a thick, muscular wall to take the pressure.

The trap: "artery = oxygen-rich and vein = oxygen-poor". It is usually true in the body but false in the pulmonary vessels, where the pulmonary artery carries oxygen-poor blood to the lungs and the pulmonary veins carry oxygen-rich blood back. Direction, not oxygen, defines the vessel.

11. Blood components — which part carries oxygen

Which part of the blood carries oxygen to the tissues?

  1. Plasma is the liquid part, and it carries dissolved substances — but oxygen does not dissolve well enough to supply the body.
  2. Oxygen is carried bound to a protein called hemoglobin.
  3. Hemoglobin sits inside the red blood cells, so that is the part that carries oxygen.

The trap: naming plasma because it is the largest part of the blood, or naming white blood cells because "blood cell" sounds like the oxygen job. White cells defend; red cells carry.

12. The heart's conduction path — put the stations in order

Which list is the correct order of the heart's own electrical signal?

  1. Each beat starts in the SA node, the pacemaker in the wall of the right atrium.
  2. The signal reaches the AV node at the atrial–ventricular boundary, where it is delayed so the atria finish emptying before the ventricles squeeze.
  3. It then travels down the AV bundle (the bundle of His) into the bundle branches and out through the Purkinje fibers, which is why the ventricles contract from the bottom up — so the order is SA node → AV node → AV bundle → bundle branches → Purkinje fibers.

The trap: putting the AV node before the SA node, or the Purkinje fibers before the bundle branches. The signal always starts at the SA node (the pacemaker) and ends at the muscle.

13. Cardiac output — heart rate × stroke volume

A heart beats 72 times per minute and ejects 65 mL of blood with each beat. What is the cardiac output?

  1. Cardiac output is the volume pumped in one minute, so every quantity has to be per minute or per beat — and here both already are.
  2. Multiply: heart rate × stroke volume = 72 beats per minute × 65 mL per beat.
  3. The beats cancel, leaving 4,680 mL per minute — that is the cardiac output.

The trap: adding the two numbers instead of multiplying them, or dividing the stroke volume by the heart rate. Cardiac output is a product: more beats per minute or more blood per beat, either one, raises it.

S.1.4 — The digestive system

The digestive system is a tube with helpers hanging off it. Food travels the tube in one direction while the body breaks it into molecules small enough to absorb; the helpers add the chemicals the tube cannot make for itself.

Table 13 — The parts of the digestive system.

Question What it does
What is the job of the Mouth? teeth break the food up and the tongue mixes it; saliva begins starch digestion
What is the job of the Pharynx? the throat; the shared passage where a swallow sends food toward the esophagus
What is the job of the Esophagus? the muscular tube to the stomach; food is pushed down by peristalsis, wave-like contractions
What is the job of the Stomach? churns food into a paste and adds acid and enzymes; protein digestion begins here
What is the job of the Small intestine? where most digestion is finished and almost all nutrients are absorbed — through finger-like villi
What is the job of the Large intestine (colon)? absorbs the water that is left and some vitamins, and forms the waste into feces
What is the job of the Rectum? stores the feces until it leaves the body
What is the job of the Anus? the exit of the tube

Table 14 — The path food takes, mouth to anus.

Question What happens there
What happens at the Mouth station on the food's path? chewing, plus saliva, which starts breaking starch down
What happens at the Pharynx station on the food's path? the swallow sends the food into the esophagus
What happens at the Esophagus station on the food's path? peristalsis pushes the food down
What happens at the Stomach station on the food's path? churning plus acid and enzymes make a paste; protein digestion starts
What happens at the Small intestine station on the food's path? digestion finishes and nutrients are absorbed: sugars and amino acids into the blood, most fat into the lymph
What happens at the Large intestine station on the food's path? the water that is left is absorbed and the waste is formed into feces
What happens at the Rectum station on the food's path? the feces wait here
What happens at the Anus station on the food's path? the feces leave the body

Digestion happens in stages, and the stage is the question. A carbohydrate starts breaking down in the mouth (saliva) and is finished in the small intestine; a protein starts in the stomach (acid and enzymes) and is finished in the small intestine; a fat is hardly digested at all before the small intestine — there it is emulsified by bile and broken down. Absorption is just as orderly: most nutrients are absorbed in the small intestine, but into two different places — the sugars and amino acids cross into the blood capillaries of the villi, and most of the fat crosses into the villi's lymph vessel, the lacteal, and reaches the blood from there. Much of the water is absorbed along the same stretch. The water that is left is reclaimed by the large intestine, which is also where the waste is formed into feces.

Table 15 — Where each nutrient class is digested, and where it is absorbed.

Question Where digestion starts Finishes in Notes
Where does digestion start for Carbohydrates? mouth — saliva begins it the small intestine starch is the common example
Where does digestion start for Proteins? stomach — acid and enzymes begin it the small intestine the stomach is where protein digestion starts, not where it ends
Where does digestion start for Fats (lipids)? mouth and stomach — only a trace, and the two enzymes are lingual lipase from glands of the tongue (released into the saliva) and gastric lipase from the chief cells the small intestine bile emulsifies fat so enzymes can reach it; only a trace of fat is digested before the small intestine, so most of it happens there
Does water need digestion before it is absorbed? No — it is absorbed as it is the small intestine, then the large intestine most of it is taken up in the small intestine along with the nutrients
Do sugars, amino acids and fatty acids need digestion before they are absorbed? The small ones do not — they are absorbed as they are the small intestine absorbed through the villi: sugars and amino acids into the blood, most fat into the lymph (the lacteals)

Table 16 — The accessory organs: the helpers that are not the tube.

Question What it adds, and where it goes
What do the salivary glands add, and where does it go? saliva, which moistens food and begins starch digestion — into the mouth
What does the Liver add, and where does it go? makes bile — sends it to the gallbladder
What does the Gallbladder add, and where does it go? stores bile and releases it — into the small intestine, where bile emulsifies fat
What does the Pancreas add, and where does it go? adds digestive enzymes and bicarbonate — into the small intestine (and, in its other job, it is an endocrine gland that releases insulin and glucagon)

The pancreas is the clearest example of a structure that belongs to two systems at once (the diaphragm, the pharynx and the gonads are others). The digestive pancreas releases enzymes into the small intestine; the endocrine pancreas releases hormones into the blood (that is S.1.9's material). An exam question about it will name either the system or the function — read which one it named.

14. Digestive organs — the organ that absorbs most nutrients

Most of the nutrients from a meal are absorbed where?

  1. The stomach churns food and begins protein digestion, but very little absorption happens there.
  2. The small intestine is the long, folded tube whose villi give it an enormous surface.
  3. Surface is what absorption needs, so most nutrients are absorbed in the small intestine — and the water that the body keeps comes with them, along the same stretch. What is left for the large intestine is the water still in the waste, which it reclaims before forming it into feces.

The trap: choosing the large intestine because it is late in the path, or the stomach because it is where food stops being food. Finishing digestion and absorbing nutrients are the small intestine's jobs.

15. The food pathway — put the stations in order

Which list is the correct path of food through the digestive tube?

  1. A swallow sends the food from the mouth to the pharynx, and the esophagus carries it down with peristalsis.
  2. The stomach churns it, and then the small intestine finishes digesting it and absorbs the nutrients.
  3. What is left passes to the large intestine, then the rectum and the anus — so the order is mouth → pharynx → esophagus → stomach → small intestine → large intestine → rectum → anus.

The trap: putting the large intestine before the small one. Food takes the small intestine first; the large intestine is the last stretch of the tube, and water is what it reclaims.

16. Digestion and absorption — where a class is digested

Where does most of the digestion of fat happen?

  1. Fat does not dissolve in the watery contents of the mouth or the stomach, so only a little of it is digested before the small intestine.
  2. Fat has to be broken into droplets first, and the substance that does that is bile.
  3. Bile is released into the small intestine, so most fat digestion happens there — not in the mouth like starch and not in the stomach like protein.

The trap: assuming every nutrient is digested in one place. Starch starts in the mouth, protein in the stomach, and most fat is digested in the small intestine — and each of those three is a favorite exam question.

17. Accessory organs — who adds what

Which organ makes bile?

  1. Bile is made for fat digestion and it is stored before it is used, so making and storing are two different organs.
  2. The liver is the organ that makes bile.
  3. The gallbladder only stores it and releases it into the small intestine.

The trap: naming the gallbladder because that is where bile waits. Making and storing are the liver's and the gallbladder's jobs respectively — the same trap as the pancreas's two jobs.

Answer-choice strategies: three moves for a path item

Pathway questions (air, blood, food) look harder than they are, because every choice is a version of the same list: reordered, or with a station left out. Do these three things and the answer appears.

1. Find the start and the end in the stem. "Starting from the right atrium…" and "…before it reaches the body" tell you the first and last stations. Cross out any choice whose first or last station is wrong. In many items every choice shares the same first and last station, and then the middle is the whole question: go to move 3.

2. Say the direction out loud, not the order. Every pathway in this topic has a direction sentence: air goes in through the nose; the right side of the heart sends blood to the lungs and the left side sends it to the body; food goes down and urine goes out; an impulse travels from the dendrites toward the axon terminals. If a choice reverses a direction, it is gone, however plausible its middle looks.

3. Hunt the swap. The most common wrong choice is the correct order with two neighboring stations swapped — bronchioles before bronchi, the AV node before the SA node, the large intestine before the small one. Read the choice one station at a time rather than recognizing the set of names; recognizing the names is exactly what the item is built to punish.

And one move for a naming item: when a structure belongs to two systems (the pancreas, the diaphragm, the ovary, the testes), read whether the stem named the system or the function, and answer that one. If the stem asks what the liver does for digestion, do not answer with the liver's other job.

S.1.5 — The nervous system

The nervous system is the body's wiring and its control room: cells that carry an electrical signal fast, and organs that decide what the signals should say. It is the system whose vocabulary trips people up most, because it comes in pairs — central and peripheral, somatic and autonomic, sympathetic and parasympathetic, sensory and motor.

A neuron is one cell with three working parts plus its output. Dendrites receive signals and carry them toward the cell body; the cell body holds the nucleus and decides whether to pass the signal on; a single long axon carries the signal away from the cell body; and the axon terminals pass it to the next cell — another neuron, a muscle or a gland.

Table 17 — The parts of a neuron.

Question What it does
What is the job of the Dendrites? receive signals from other cells and carry them toward the cell body
What is the job of the Cell body? holds the nucleus; adds up the signals and starts one if they are strong enough
What is the job of the Axon? one long fiber that carries the signal away from the cell body
What is the job of the Axon terminals? the endings that pass the signal to the next neuron, muscle or gland
What is the job of the Myelin sheath? a fatty wrapping around some axons that speeds the signal up

The impulse travels one way, in one order. A signal arrives at the dendrites, reaches the cell body, travels down the axon, and leaves at the axon terminals — and a neuron with a myelin sheath carries it faster, because the signal can jump between the gaps in the wrapping instead of crawling along every millimeter of the membrane.

Table 18 — The path of a nerve impulse, one neuron long.

Question Station What happens
Where does a nerve impulse enter a neuron? dendrites receive the signal, from another neuron or a sense organ
After the dendrites, where does the signal go? the cell body the signal is summed; if it is strong enough a new impulse starts
After the cell body, what carries the impulse away? the axon the impulse travels away from the cell body, down the fiber
After the axon, where does the impulse leave? the axon terminals the impulse is passed on — to the next neuron, a muscle or a gland

The wiring comes in two divisions, and then the second one splits again. The central nervous system (CNS) is the brain and the spinal cord — the control room. The peripheral nervous system (PNS) is everything else: the nerves that carry information in and commands out. The PNS itself has a voluntary part — the somatic nervous system, which moves your skeletal muscles — and an involuntary part, the autonomic nervous system, which runs the organs you do not consciously control.

Table 19 — The divisions of the nervous system.

Question What it is Its job
What is the Central nervous system (CNS)? the brain and the spinal cord processes information and decides what to do
What is the Peripheral nervous system (PNS)? all the nerves outside the brain and spinal cord carries information in and commands out
What is the Somatic nervous system? the PNS nerves serving the skeletal muscles voluntary movement — muscles you decide to move
What is the Autonomic nervous system? the PNS nerves serving the organs involuntary control of the heart, glands and gut
What is the Sympathetic division? the autonomic division that prepares the body for action speeds the heart, widens the airways — the fight-or-flight branch
What is the Parasympathetic division? the autonomic division that restores and rests slows the heart, drives digestion — the rest-and-digest branch

The brain's three big regions have three different jobs. The cerebrum is the folded upper part: thinking, memory, language, and the conscious control of movement. The cerebellum sits at the back underneath: coordination, balance and smooth movement. The brain stem is the stalk below: the involuntary functions that cannot pause — breathing, heart rate, blood pressure.

Table 20 — The regions of the brain.

Question Where it is What it does
Where is the Cerebrum? the folded upper part thinking, memory, language and conscious movement
Where is the Cerebellum? at the back, beneath the cerebrum coordination, balance and smooth movement
Where is the Brain stem? the stalk below, joining the spinal cord involuntary basics — breathing, heart rate, blood pressure

18. Neuron parts — which end receives, which end sends

Which part of a neuron receives signals from other cells?

  1. A neuron has one output fiber and one receiving zone, so the question is which is which.
  2. The axon is the output: it carries the signal away from the cell body to its terminals.
  3. The receiving zone is the dendrites — the branched endings that carry signals toward the cell body.

The trap: swapping the two. Dendrites receive; the axon sends. A question that says "away from the cell body" is describing the axon.

19. The impulse path — put the stations in order

Which list shows the order in which a nerve impulse travels through one neuron?

  1. The signal arrives from another cell, so it enters where signals enter: the dendrites.
  2. From the dendrites it reaches the cell body, which sums what arrived and starts a new impulse if the signal is strong enough.
  3. The impulse then travels down the axon and leaves at the axon terminals — so the order is dendrites → cell body → axon → axon terminals.

The trap: running the impulse backwards, or putting the terminals before the axon. A neuron is a one-way street, and the direction is written into its parts.

20. The nervous-system divisions — which one is voluntary

Which division of the nervous system carries the commands to the muscles you decide to move?

  1. Start with the two big divisions: the CNS (brain and spinal cord) and the PNS (all the nerves).
  2. The brain decides, but the nerves that carry the command to a muscle belong to the peripheral system — and inside it, the division serving skeletal muscle is the somatic one.
  3. So the voluntary commands run through the somatic nervous system, while the heart, glands and gut are run by the autonomic system without your deciding.

The trap: reading "central" as "the part you control", and "autonomic" as "automatic movement". Autonomic means automatic organs; somatic means the muscles you move on purpose.

21. Brain regions — which part does which job

A person's balance and coordination are affected. Which region of the brain is most involved?

  1. Balance and coordination are not thinking or memory, so the cerebrum is not the region in question.
  2. The region behind and beneath the cerebrum, specialized for coordination and balance, is the cerebellum.
  3. The brain stem is the other candidate — but it runs breathing, heart rate and blood pressure, not balance.

The trap: picking the brain stem because it sounds like the "basic" part of the brain. Breathing and heart rate are the brain stem; balance and smooth movement are the cerebellum.

S.1.6 — The muscular system

Muscle does one thing: it pulls, and it pulls by shortening. Every question about muscle is really one of three: which kind of muscle is this, how does it shorten, and which muscle does this movement.

Three kinds of muscle, told apart by three questions. Is it voluntary? Is it striated (banded under a microscope)? Where is it? Skeletal muscle is voluntary, striated, and attached to bone. Smooth muscle is involuntary, not striated, and sits in the walls of hollow organs and vessels. Cardiac muscle is involuntary but striated, and is found only in the heart wall.

Table 21 — The three muscle types.

Question Voluntary? Striated? Where it is
Is Skeletal muscle voluntary? voluntary striated attached to bones — movement you decide on
Is Smooth muscle voluntary? involuntary not striated the walls of hollow organs and blood vessels — the gut, the bladder, the airways
Is Cardiac muscle voluntary? involuntary striated the heart wall only

How a muscle shortens: the sliding-filament idea. A skeletal muscle fiber is full of two protein filaments — thin actin and thick myosin. When a signal arrives, calcium is released inside the fiber, and the myosin heads pull the actin filaments toward the center of the sarcomere. The filaments themselves do not get shorter; they slide, so the whole fiber shortens and pulls on what it is attached to. The pull needs ATP as its energy, and when the signal stops, the calcium is pumped away and the muscle relaxes.

Table 22 — How a muscle contracts and relaxes (the level the exam uses).

Question What happens
What starts a muscle contraction? A nerve impulse reaches the muscle fiber, and calcium is released inside it
Once calcium is released, what do the myosin heads do? attach to the thin actin filaments and pull them toward the center of the sarcomere
What does that pulling accomplish? The filaments slide, the fiber shortens, and it pulls on the bone it is attached to — work paid for with ATP
How does a muscle contraction end? The signal stops, calcium is pumped away, and the muscle relaxes

Muscles work in pairs, and the words for them come in pairs too. A muscle's origin is the end that stays put; its insertion is the end that moves. A flexor bends a joint; an extensor straightens it. The muscle doing the movement is the agonist; the one that relaxes to let it happen (and does the opposite movement) is the antagonist. Muscle is tied to bone by a tendon; bone is tied to bone by a ligament — that pair is a favorite question.

Table 23 — The two muscle pairs the questions are built on.

Question Where it is Its main action
Where is the Biceps brachii? the front of the upper arm flexes the elbow
Where is the Triceps brachii? the back of the upper arm extends the elbow
Where are the quadriceps? the front of the thigh extends the knee
Where are the hamstrings? the back of the thigh flexes the knee

The muscles worth recognizing. The same read-the-action rule answers a question about any named muscle, so know these by their job: the deltoid raises the arm out to the side; the pectoralis major pulls the arm forward and across the chest; the rectus abdominis bends the trunk forward; the trapezius raises and rotates the shoulders; the latissimus dorsi pulls the arm down and back; the gluteus maximus extends the hip; the gastrocnemius points the foot down, as in standing on tiptoe; and the diaphragm, the floor of the chest cavity, is the muscle whose contraction draws air in (S.1.2).

22. Muscle types — voluntary or not

Which muscle type is involuntary but striated?

  1. Take the two questions in order: is it voluntary, and is it striated? Skeletal muscle is voluntary, so it is out.
  2. Smooth muscle is involuntary — but it is not striated.
  3. The muscle that is involuntary and striated is cardiac muscle, found only in the heart wall.

The trap: treating "striated" as a synonym for "voluntary". Cardiac muscle is the one type that is striated and still runs on its own.

23. Muscle contraction — what slides, and what is needed

In the sliding-filament model, what actually happens when a muscle fiber shortens?

  1. The filaments that do the pulling are the thin actin and the thick myosin inside the fiber.
  2. The myosin heads attach to the actin and pull the actin filaments toward the center of the sarcomere; the filaments slide past one another rather than shrinking.
  3. The fiber shortens because the filaments overlap more, and the work is paid for with ATP — with calcium released to start it.

The trap: saying the filaments themselves get shorter, or that the muscle needs no ATP. Nothing inside shortens; things slide, and the energy bill is ATP.

24. Muscle actions — agonist and antagonist

The biceps brachii flexes the elbow. What does the triceps brachii do when the biceps contracts?

  1. Muscles work in opposing pairs at a joint, so the partner of a flexor is an extensor.
  2. Extending the elbow straightens the joint.
  3. So while the biceps (the agonist) shortens, the triceps (the antagonist) relaxes and lengthens to let the movement happen — and does the opposite movement itself.

The trap: saying both muscles contract at once, or that the antagonist is the muscle that "helps". Helping is not the job of an antagonist; opposing is.

25. Major muscles — which muscle does this action

Which muscle extends the knee?

  1. Extending the knee straightens the leg, and the muscles that do it sit on the front of the thigh.
  2. The back of the thigh holds the hamstrings, which flex the knee — the opposite action.
  3. The front-of-thigh group that straightens the knee is the quadriceps.

The trap: answering hamstrings by matching "thigh" to the word in the question. Read the action the question asks for — flex or extend — and then choose the side of the limb that performs it.

S.1.7 — The male and female reproductive systems

One objective covers two systems, so questions come in matched pairs: which structure is this, what does it make, and which hormone does the gonad release. Learn the two systems side by side and the pairs answer each other.

The male system makes sperm and delivers it. Sperm are made in the testes, which also release testosterone. Sperm then mature and are stored in the epididymis, travel up the vas deferens, and fluid from the seminal vesicles, the prostate and the bulbourethral glands joins them on the way out, forming semen — which leaves the body through the urethra, the tube that also carries urine.

Table 24 — The male reproductive structures.

Question What it does
What is the job of the Testes? make sperm, and release testosterone
What is the job of the Epididymis? stores sperm and lets them mature
What is the job of the Vas deferens? the tube that carries sperm away from the epididymis
What is the job of the Seminal vesicles? add the largest share of the fluid that carries the sperm
What is the job of the Prostate? a gland just below the bladder, around the urethra; adds fluid to the sperm
What is the job of the Bulbourethral glands? small glands that add a little fluid before the sperm are released
What is the job of the Urethra? the tube semen leaves the body through — the same tube that carries urine

The penis is the organ that delivers semen, the last station of the same route.

Three kinds of gland add the fluid, and each adds its own share. The seminal vesicles add the largest share; the prostate sits just below the bladder and surrounds the urethra, and adds fluid there; the bulbourethral glands add a small amount before the rest. Sperm plus that fluid is semen, and the glands' three jobs are a favorite exam trap: the question may name the gland and ask what it adds, or describe the fluid and ask which gland added it.

The female system produces eggs, receives sperm and houses development. Eggs are made in the ovaries, which also release estrogen and progesterone. An egg leaves an ovary and travels through a fallopian tube toward the uterus; the uterus is the organ where a fertilized egg implants and develops. The cervix is the narrow neck of the uterus, and the vagina is the passage that receives sperm and is the birth canal.

Table 25 — The female reproductive structures.

Question What it does
What is the job of the Ovaries? make eggs, and release estrogen and progesterone
What is the job of the Fallopian tubes? carry the egg from the ovary toward the uterus — and are where fertilization happens
What is the job of the Uterus? the organ where a fertilized egg implants and develops
What is the job of the Cervix? the narrow neck at the bottom of the uterus
What is the job of the Vagina? the canal that receives sperm, and the birth canal

Both gonads make two things: a gamete and hormones. This is the one idea the two systems share, and it is the source of the section's most common distractor: the testes and the ovaries are named in the endocrine system too, so a question that asks about a hormone is not asking about a reproductive structure's shape.

Table 26 — The gametes, and the hormones the gonads make.

Question The gamete it makes The hormones it makes
Which gamete do the testes make? sperm testosterone
Which gamete do the ovaries make? eggs estrogen and progesterone

26. Male reproductive structures — where sperm mature

Where do sperm mature and wait before ejaculation?

  1. Sperm are made in the testes, but they are not stored there.
  2. The structure that sits on the back of each testis, where sperm mature and are kept, is the epididymis.
  3. From there they travel up the vas deferens — so the vas deferens carries them, and the epididymis is where they were waiting.

The trap: naming the vas deferens for storage. The vas deferens is the road; the epididymis is the parking lot.

27. Female reproductive structures — where fertilization happens

In which structure does fertilization normally happen?

  1. The egg leaves the ovary and is moved along by the fallopian tube toward the uterus.
  2. Fertilization is the joining of sperm and egg, and it happens in the tube, not in the uterus itself.
  3. The fallopian tube is therefore the site of fertilization; the uterus is where a fertilized egg implants and develops.

The trap: answering "uterus" because that is where development happens. The uterus houses the developing egg; the tube is where it is fertilized.

28. Gametes and gonadal hormones — which organ makes which

Which organ releases testosterone?

  1. Both gonads make a gamete and hormones, so the question is which pair belongs to which organ.
  2. The testes make sperm — and the hormone they release is testosterone.
  3. The ovaries make eggs, and the hormones they release are estrogen and progesterone.

The trap: answering "the adrenal glands" because they also release a small amount of testosterone. The gonads are the primary source, and this system's questions are about the gonads.

S.1.8 — The integumentary system

The integumentary system is the skin and everything growing out of it — hair, nails, and the glands in the skin. The skin is the body's largest organ, and its functions are easy to take for granted: protection, temperature control, sensation, and vitamin D.

The skin is three layers, and each has a job. The epidermis is the thin outer layer — the barrier — and it has no blood vessels of its own, so it is fed by the layer beneath. The dermis is the thicker middle layer, and it holds what the skin needs to work: blood vessels, nerves, hair follicles and glands. The hypodermis (subcutaneous layer) is the deepest layer, just beneath the skin proper, and it is mostly fat: it insulates the body and anchors the skin to the tissue beneath.

Table 27 — The three layers of the skin.

Question Where it is What it does
Where is the Epidermis? the thin outer layer the protective barrier; no blood vessels of its own
Where is the Dermis? the thicker middle layer holds the blood vessels, nerves, hair follicles and glands
Where is the Hypodermis? the deepest layer, mostly fat insulates the body and anchors the skin to the tissues below

Accessory structures are the skin's tools. Hair grows from follicles in the dermis and helps with warmth and touch; nails protect the ends of the fingers and toes; sweat glands release sweat onto the surface, which cools the body as it evaporates; and sebaceous (oil) glands release oil that keeps the skin and hair from drying out.

Table 28 — The accessory structures of the skin.

Question What it does
What is the job of the Hair and hair follicles? grow from the dermis and help with warmth and touch
What is the job of the Nails? protect the ends of the fingers and toes
What is the job of the Sweat glands? release sweat onto the surface, which cools the body as it evaporates
What is the job of the Sebaceous (oil) glands? release oil that keeps the skin and hair from drying out

Four functions, and each has a mechanism. The skin protects — it is a physical barrier, and its acid surface discourages microbes. It regulates temperature — sweating cools you, and the blood vessels in the dermis widen to release heat or narrow to keep it. It senses — the nerves in the dermis report touch, pressure, pain and temperature. And it makes vitamin D — when sunlight reaches the skin, the skin starts the reaction that produces it.

Table 29 — The functions of the skin.

Question How the skin does it
How does the skin achieve Protection? a physical barrier, with an acid surface that discourages microbes
How does the skin achieve Temperature control? sweating cools the body; blood vessels in the dermis widen to release heat or narrow to keep it
How does the skin achieve Sensation? the nerves in the dermis report touch, pressure, pain and temperature
How does the skin achieve Vitamin D production? sunlight reaching the skin starts the reaction that makes vitamin D

29. Skin layers — which layer has the blood vessels

Which layer of the skin contains the blood vessels and nerves?

  1. The outer layer is the epidermis, and it has no blood vessels of its own — which is why a scrape that stays in the epidermis does not bleed.
  2. Beneath it sits the dermis, the thicker layer that carries the vessels, nerves, follicles and glands.
  3. The hypodermis is deeper still, and mostly fat — it insulates rather than supplying.

The trap: putting the vessels in the epidermis because that is the layer you can see. The visible layer is the one with no blood supply at all.

30. Accessory structures — which gland does what

Which glands release oil that keeps the skin from drying out?

  1. The skin has two kinds of gland, and they release different things: sweat glands release sweat, which cools the body.
  2. Cooling is not the job described in the question — the question asks about oil.
  3. The sebaceous (oil) glands release the oil; sweat glands release sweat.

The trap: answering "sweat glands" whenever a gland is mentioned. Ask what the question says the gland releases: sweat for cooling, oil for waterproofing the skin and hair.

31. Skin functions — how the body cools itself

On a hot day the body cools itself mainly by which mechanism of the skin?

  1. The skin has four functions, so read which one the question names: cooling.
  2. Protection, sensation and vitamin D production do not lower body temperature.
  3. Sweating cools the body as the sweat evaporates from the surface — helped by the dermis's blood vessels widening to release heat.

The trap: naming "the blood vessels widening" alone. Widening the vessels helps too, but the question asks how the skin cools the body, and the mechanism that does it by name is sweating.

S.1.9 — The endocrine system

The endocrine system is the body's chemical messaging: glands release hormones into the blood, and each hormone travels to the cells that answer it. Beside the nervous system of S.1.5 it is slower to start and slower to stop — but it reaches everywhere the blood goes, and its effects last. The wiring is the nervous system; the broadcast is the endocrine system.

Every hormone question is three questions: which gland makes it, what it acts on, and what it changes. Learn each hormone as that sentence and this section stops being a list of names. It is also where this system crosses S.1.4 and S.1.7: the pancreas releases insulin and glucagon and adds digestive enzymes, and the ovaries and testes release the hormones S.1.7 already gave them. Read which of the two the question names — a question about the pancreas that asks about enzymes and food belongs to the digestive system, and one that asks about a hormone belongs here.

Table 30 — The endocrine glands, and the hormones each one releases.

Question Where it is The hormones it releases
Where is the Pituitary? at the base of the brain growth hormone, antidiuretic hormone (ADH) and oxytocin — and the signals that tell other glands what to do
Where is the Hypothalamus? the base of the brain, just above the pituitary makes ADH and oxytocin, which the pituitary stores and releases — the link between the nervous system and the endocrine system
Where is the Thyroid? in the neck, in front of the trachea thyroid hormones (they set the body's metabolic rate) and calcitonin
Where is the Parathyroid? four small glands on the back of the thyroid parathyroid hormone (PTH)
Where are the adrenal glands? one on top of each kidney cortisol and epinephrine
Where is the Pancreas? behind the stomach insulin and glucagon — and, in its other job, the digestive enzymes it sends to the small intestine
Where is the Pineal? in the brain melatonin
Where are the ovaries (female)? in the pelvis estrogen and progesterone
Where are the testes (male)? below the pelvis testosterone

Table 31 — What each hormone changes.

Question From Its main effect
Which gland does Growth hormone come from? pituitary drives growth, especially of bones and muscles
Which gland do antidiuretic hormone (ADH) and oxytocin come from? pituitary ADH tells the kidneys to keep water, so less urine is made; oxytocin makes the uterus contract
Which gland do thyroid hormones come from? thyroid set the rate at which the body's cells use energy
Which gland does Calcitonin come from? thyroid lowers the calcium level in the blood
Which gland does Parathyroid hormone come from? parathyroid raises the calcium level in the blood
Which gland does Cortisol come from? adrenal glands helps the body through long-lasting stress; it raises the glucose level
Which gland does Epinephrine come from? adrenal glands the fast stress hormone — it speeds the heart and widens the airways
Which gland does Insulin come from? pancreas moves glucose out of the blood and into the cells
Which gland does Glucagon come from? pancreas raises the glucose level in the blood by making the liver release glucose
Which gland does Melatonin come from? pineal helps set the body's sleep–wake rhythm
Which gland does Estrogen come from? ovaries female secondary sex characteristics, and the lining changes of the reproductive cycle
Which gland does Progesterone come from? ovaries prepares the lining of the uterus for a fertilized egg
Which gland does Testosterone come from? testes male secondary sex characteristics, and sperm production

Two hormones in that table are a pair, and the pair is the question. Insulin and glucagon do opposite jobs to the same substance: insulin lowers the glucose level by moving glucose out of the blood and into the cells, and glucagon raises it by making the liver release glucose. Calcitonin and parathyroid hormone are the same shape of pair for calcium: calcitonin lowers the calcium level and parathyroid hormone raises it. The two hormones act on bone first, and also on the kidney (and, for parathyroid hormone, on the intestine too) — so calcium is the bone's store and the kidney's balance as well as the hormone pair's business. When a question names one of a pair, the other is the distractor — and the direction is the whole answer.

Table 32 — Negative feedback, worked with ADH.

Question What happens when the body is low on water
When the body is low on water, what happens to the blood? the body loses water, and the blood becomes more concentrated
What does that concentrated blood make the pituitary release? ADH into the blood
What does ADH change in the kidney? the kidneys take water back instead of passing it into the urine
What stops the ADH signal once the blood is diluted again? water is kept, the blood is diluted again, and the pituitary slows or stops releasing ADH

That loop is what "negative feedback" means: the response cancels the change that started it, and because the body keeps checking the level, the release falls back as soon as the level is back. Almost every hormone in Table 31 is controlled this way — oxytocin is the exception: its loop pushes the level higher until the process it began is finished (positive feedback). The exam question is usually the last step — what happens to the gland once the level is back to normal? — and the answer is that the gland slows or stops releasing the hormone, not that it keeps going at the same rate.

32. Endocrine glands — which gland releases which hormone

The adrenal glands sit on top of the kidneys. Which two hormones do they release?

  1. "Adrenal" names the gland's position, not its hormones, so the question is a recall of the pair — and the pair is the two stress hormones, not the two glucose hormones.
  2. Cortisol works on stress that lasts, and epinephrine is the fast one: it speeds the heart and widens the airways in a moment.
  3. So the answer is cortisol and epinephrine. Insulin and glucagon belong to the pancreas; ADH and oxytocin belong to the pituitary.

The trap: answering with the pair from another gland's row. Learn Table 30 one gland at a time — a question names the gland, and the gland's row is the answer.

33. Hormone action — what a hormone changes

After a meal, the glucose level in the blood rises. Which hormone answers it, and what does the hormone do?

  1. The body keeps checking the glucose level, so read which way the level has moved: it has moved up.
  2. The hormone that answers a raised glucose level is insulin, from the pancreas. Its partner, glucagon, is the hormone for the opposite direction.
  3. Insulin moves glucose out of the blood and into the cells, which brings the level back down — and once the level is back, the pancreas slows or stops releasing it. That is the negative-feedback loop of Table 32.

The trap: naming glucagon because it is the pancreas's other hormone. Glucagon's direction is the opposite one — it raises the glucose level. Read the direction the question gives, and answer with the hormone that moves it back.

S.1.10 — The urinary system

The urinary system filters the blood and carries the waste out as urine — and on the way it decides how much water and salt the body keeps. That second job is why the system matters beyond waste: it is where the body's water balance is settled. The system's parts are a pair of filters and a one-way plumbing run, and a question about it is usually a question about which part, and which direction.

Table 33 — The urinary organs.

Question What it does
What is the job of the Kidneys? filter the blood and make urine; they also keep the body's water, salt and acid in balance
What is the job of the Ureters? two tubes, one from each kidney, that carry urine from the kidney to the bladder
What is the job of the Bladder? a muscular sac that stores urine until it is released
What is the job of the urethra in the urinary path? the tube urine leaves the body through

Table 34 — The path urine takes, out of the body.

Question What happens there
In the urinary path, what happens at the kidney station? the blood is filtered, and the fluid that will become urine is made
In the urinary path, what happens at the ureter station? the fluid is carried down to the bladder; there is one ureter per kidney
In the urinary path, what happens at the bladder station? the urine is stored until the bladder's muscle contracts
In the urinary path, what happens at the urethra station? the urine leaves the body

Look at the two easy-to-confuse names in that path. The ureter carries urine from the kidney to the bladder; the urethra carries urine from the bladder out of the body. They differ by two letters and by one whole station, and swapping them is this system's signature mistake — a question usually settles it by naming the station on either side.

Table 35 — The kidney's three jobs, in outline.

Question What it means
What does Filtration mean? water, salts and small wastes are filtered out of the blood, into the kidney's tubules
What does Reabsorption mean? useful material — most of the water, and the glucose, the salts and the calcium the body needs — is taken back into the blood before the fluid leaves
What does Secretion mean? waste that was not filtered is moved out of the blood into the fluid, so it leaves with the urine

Those three jobs are why urine is not simply filtered blood. Filtration is indiscriminate: it takes water and small molecules and leaves the cells and the large proteins behind. Reabsorption is the picky step that keeps what the body needs, and it is the step that makes the volume of urine a decision rather than a result. Secretion is the small top-up that moves a few wastes in the other direction. The exam asks which job does what: water kept → reabsorption, waste moved in → secretion, blood separated → filtration.

The kidney's balance job is the other half of its work, and it is broader than water. Besides making urine, the kidney keeps the water, the salts and minerals and the acid of the body in range — and the calcium too, with the endocrine section's hormone pair setting how much of it is taken back. That is why the volume of urine rises and falls with what the body needs: the kidney is holding a level.

34. Urinary organs — which organ does which job

Urine is stored until it can be released. Which organ stores it?

  1. The system has four parts, and each has one sentence: the kidney filters, the ureter carries, the bladder stores, the urethra releases.
  2. Storage is the bladder's sentence.
  3. So the answer is the bladder — a sac of muscle, which is why the urine leaves when that muscle contracts.

The trap: answering "the kidney" because the question is about urine. The kidney makes urine; the bladder keeps it.

35. The urine pathway — where urine goes next

Urine is made in a kidney. Which tube does it enter first, and where does that tube take it?

  1. Two tubes leave the kidneys, one from each, and they are the ureters.
  2. A ureter carries urine down to the bladder, where the urine waits.
  3. From the bladder the urine leaves through the urethra — so the path is kidney → ureter → bladder → urethra, and the tube that leaves the kidney is the ureter, not the urethra.

The trap: the pair of look-alike names. If the sentence says "from the kidney", the answer is the ureter; if it says "out of the body", it is the urethra.

36. Urine formation — which job does what

Most of the water that is filtered out of the blood never leaves the body. Which job brings it back?

  1. Filtration takes water and small wastes out of the blood and into the kidney's tubules — it does not bring anything back.
  2. Reabsorption is the step that takes useful material back into the blood: most of the water, and the glucose and salts the body needs.
  3. So the answer is reabsorption. Secretion runs the other way — the small top-up that moves a few wastes out of the blood and into the fluid that will leave.

The trap: reading "filtered out" as the whole story. Filtration makes a fluid that is mostly water; reabsorption is what turns it into the small volume of urine that leaves.

S.1.11 — The immune system

The immune system is the body's defense against what gets in — microbes, and anything else the body does not recognize as its own. Its innate defenses are the ones the body is born with, and they work in two steps: the barriers — the skin, the mucous membranes, the acid on the skin and in the stomach — and then a fast general response. Behind them sits the adaptive response, which is slower, targets one thing and remembers it. Three words carry the section: innate (general, no memory — the barriers and the fast response), adaptive (specific, with memory) and antigen (the part of a foreign cell or molecule the immune system recognizes).

Table 36 — The body's defenses, in three layers.

Question What it is What it does
What are the barriers (the first part of innate defense)? the skin, the mucous membranes, the acid on the skin and in the stomach keep most microbes out, or kill them where they land
What is the Innate (general) immunity? phagocytes — white blood cells that engulf — plus fever and a rush of blood to the site attacks anything foreign the same way, quickly, and keeps no memory
What is the Adaptive (specific) immunity? lymphocytes — B cells and T cells — and the antibodies they make targets one specific antigen, and leaves memory cells behind

Memory is the difference the exam tests. The innate response meets a microbe it has never seen as though it had seen nothing at all. The adaptive response changes the body for a long time: the first meeting takes days, and the second meeting with the same antigen is fast and strong, because the memory cells are already there. That is what immunity means.

Table 37 — The lymphatic structures.

Question What it does
What is the job of the Lymph? the fluid that bathes the body's cells, called lymph once the lymphatic vessels collect it; it is returned to the blood in large veins near the heart
What is the job of the Lymphatic vessels? carry lymph away from the tissues and back toward the heart
What is the job of the Lymph nodes? filter the lymph and hold lymphocytes, so a microbe traveling in lymph meets them there
What is the job of the Spleen? filters the blood and holds lymphocytes
What is the job of the Thymus? the organ where T cells mature

Table 38 — The white blood cells, and how antibodies work.

Question What it does
What is the job of Phagocytes? engulf and digest microbes and debris — the innate response's workhorse
What is the job of B cells? lymphocytes that make antibodies that stick to one specific antigen
What is the job of Antibodies? stick to their antigen, mark it so phagocytes can engulf it, and stop it working
What is the job of T cells? help the rest of the response, and destroy body cells that a microbe has taken over
What is the job of Memory cells? stay behind after the response ends, so the next meeting with the same antigen is faster

Antibodies do not eat anything; they mark and disable. An antibody fits one antigen — the fit is the specificity — and its work is to flag that antigen for the phagocytes and to stop it working. That is why the first meeting with an antigen is slow (the body has to find the right B cell) and the second is fast (the memory cells are already made and waiting).

37. Innate and adaptive immunity — which one remembers

A person meets the same microbe twice, and the second meeting is dealt with faster and more strongly than the first. Which part of the immune system explains that?

  1. Split the system into its two working responses first: the innate response is general and keeps no memory, and the adaptive response targets one antigen and leaves memory cells.
  2. The barrier layer cannot explain it — the barrier does not change when the same microbe returns.
  3. The adaptive response explains it, because the memory cells left from the first meeting are already there, so the second answer needs no time to find the right B cell.

The trap: crediting the innate response with memory because it acted first. The innate response is the fast, general one; the remembering one is the adaptive response.

38. Lymphatic structures — where lymph is filtered

Which structure filters lymph, and holds the lymphocytes that meet what it carries?

  1. Work out what the question asks the structure to filter: lymph or blood. Those are two different structures.
  2. The structure that filters blood is the spleen. The lymph nodes are the ones that filter lymph.
  3. So the answer is a lymph node — and the fluid it filters is the lymph collected from the tissues, traveling in the lymphatic vessels toward the heart.

The trap: answering "the spleen" for any question about filtering. The spleen filters the blood; the lymph nodes filter the lymph.

39. Antibodies and white cells — which cell does which

Which white blood cell engulfs a microbe, and which one makes antibodies?

  1. Two jobs are in the question, and they belong to two different cells: engulfing is the innate response, and antibody-making is the adaptive one.
  2. Phagocytes engulf and digest microbes and debris, and they act the same way on anything foreign.
  3. B cells make the antibodies, and an antibody sticks to one specific antigen and marks it so a phagocyte can engulf it. So the engulfing cell is the phagocyte, and the antibody-maker is the B cell.

The trap: giving the phagocyte the antibody job. Antibodies are made by lymphocytes; phagocytes do the eating.

S.1.12 — The skeletal system

The skeleton is the body's frame, and it does four jobs: it supports the body, protects the organs inside, makes movement possible by giving the muscles something to pull on, and stores minerals — and the marrow inside some bones makes blood cells. Bones are also the body's calcium store, which is why the endocrine section's calcitonin and parathyroid hormone matter here.

The skeleton divides in two, and the division decides which bone belongs where.

Table 39 — The two divisions of the skeleton.

Question What it holds
What does the Axial skeleton hold? the head and the trunk — the skull, the vertebrae, the ribs and the sternum: the parts that support and protect
What does the Appendicular skeleton hold? the limbs and the girdles that attach them — the shoulder girdle, the arms, the pelvic girdle (hip bones) and the legs

Table 40 — The named bones, and where each one sits.

Question Where it is
Where is the Cranium (skull)? the head — it protects the brain
Where is the Mandible? the lower jaw — the skull's only movable bone
Where is the Clavicle (collarbone)? the shoulder girdle, at the top of the chest
Where is the Scapula (shoulder blade)? the shoulder girdle, on the back of the chest
Where is the Sternum (breastbone)? the chest, in the middle, where the ribs meet at the front
Where are the ribs? the chest, in twelve pairs, protecting the heart and the lungs
Where are the vertebrae (spine)? the trunk, stacked along the back — they protect the spinal cord
Where is the Humerus? the upper arm
Where is the Radius? the forearm — the bone on the thumb side
Where is the Ulna? the forearm — the bone on the little-finger side
Where is the Pelvis? the hip bones — the pelvic girdle — they attach the legs to the trunk
Where is the Femur? the thigh — the longest and strongest bone in the body
Where is the Patella (kneecap)? the knee, in front of the joint
Where is the Tibia (shin bone)? the lower leg — the thicker of the two, carrying the body's weight
Where is the Fibula? the lower leg — the thinner bone beside the tibia

Bones come in five broad shapes, and the shape follows the job. A long bone is longer than it is wide, with ends wider than its shaft — the femur and the humerus, which work as levers. A short bone is roughly cube-shaped, like the bones of the wrist and the ankle. A flat bone is thin and flat, and it often protects what lies beneath: the sternum, the ribs and the skull's bones. An irregular bone has no simple shape at all — the vertebrae are the example, and their shape is the point. A sesamoid bone forms inside a tendon, and the patella is the example.

Table 41 — Inside a long bone.

Question What it is
What is Compact bone? the hard, dense outer layer
What is Spongy bone? the lighter, porous bone inside the ends
What is Bone marrow? red marrow, which makes blood cells, fills the spongy bone; the shaft's central cavity holds yellow marrow, which stores fat
What is Cartilage at the ends? the smooth covering where the bone meets another bone at a joint

Bones meet each other at joints, and the joint's shape is the movement it allows. A ligament holds bone to bone at a joint, and a tendon — S.1.6's word — holds muscle to bone. That pair is what this system and the muscular system share, and it is a favorite question: ligaments join bone to bone, tendons join muscle to bone.

Table 42 — The joint types.

Question How it moves Where
How does a Hinge joint move? back and forth, like a door the elbow, the knee
How does a Ball-and-socket joint move? in every direction, and round the shoulder, the hip
How does a Pivot joint move? turning around its own axis between the first two vertebrae of the neck, where the head turns
How does a Gliding joint move? a small sliding movement the joints between the small bones of the wrist, and between the small bones of the ankle
How does a Suture joint move? almost not at all — the bones are held together by fibrous connective tissue the seams between the skull's bones

By structure, joints come in three kinds too: fibrous (the sutures, where the bones are held together by fibrous connective tissue), cartilaginous (held together by cartilage), and synovial — every freely movable joint in the table above.

40. Skeleton divisions — which division is this bone in

The vertebrae are part of which division of the skeleton?

  1. Split the skeleton into its two divisions: the axial skeleton is the head and the trunk, and the appendicular skeleton is the limbs and the girdles that attach them.
  2. The vertebrae lie along the back, inside the trunk, and they protect the spinal cord — so they are not a limb and not a girdle.
  3. They belong to the axial skeleton, with the skull, the ribs and the sternum.

The trap: sorting by "big bone" or "small bone" instead of by place. Sort by the division's sentence: head or trunk → axial; limb or girdle → appendicular.

41. Bone types and structure — what is inside a bone

Which part of a bone is the hard, dense outer layer, and what is the soft tissue inside it called?

  1. A long bone is described in layers, from the outside in: the hard compact bone outside, the lighter spongy bone in the ends, and the marrow inside the shaft's central cavity.
  2. The hard, dense outer layer is compact bone, and it is what gives the bone its strength.
  3. The soft tissue inside is the marrow — the red marrow in the spongy bone makes the blood cells, and the yellow marrow in the shaft's cavity stores fat.

The trap: putting the marrow outside, or calling the whole bone solid. The outer layer is the dense one; the blood-making red marrow is the one inside the spongy bone at the ends.

42. Joints — which joint moves which way

Which kind of joint lets the shoulder move in every direction, and which kind is the elbow?

  1. Read the movement the question gives, because a joint's kind is its movement: back and forth → hinge; every direction → ball-and-socket; turning → pivot; sliding → gliding; almost no movement → suture.
  2. "In every direction, and round" is the ball-and-socket joint — the shoulder and the hip.
  3. Back and forth, like a door, is the hinge joint — the elbow and the knee.

The trap: naming the joint by where it is rather than by how it moves. A knee is a hinge because of its movement, not because of its size.

The traps, collected

Most wrong answers in this topic's practice items are one of these.

  • A part given another part's job: the gallbladder credited with making bile, the atrium with pumping, the epiglottis with warming the air.
  • The right organ in the wrong system: the pancreas answered as an endocrine gland when the stem asked about digestion (or the reverse).
  • A part named where a type was wanted: a tendon offered as a muscle type, or a named arm muscle offered where the stem asked for the type.
  • A station moved one step: bronchioles before the bronchi, the large intestine before the small one, the AV node before the SA node, the bicuspid valve before the pulmonary valve.
  • A direction reversed: air said to leave the alveolus as oxygen enters (the right way is oxygen in, carbon dioxide out); the diaphragm said to relax on inspiration; blood said to flow from the left ventricle to the lungs.
  • A pair of look-alike words swapped: bronchus/bronchiole, ureter/urethra (S.1.10), artery/vein read as oxygen-rich/oxygen-poor rather than toward/away from the heart.
  • Anatomical position ignored: a directional term read from the reader's viewpoint instead of the body's.
  • A plane named by the surface it exposes: "frontal" taken as the front of the body rather than the cut that separates front from back.
  • A nerve or a muscle given the other's job: a sensory structure credited with movement, an effector credited with sensation.
  • The wiring read backwards: a command said to travel from the muscle to the brain, or an impulse said to start at the axon terminals and end at the dendrites.
  • Somatic and autonomic swapped: the heart described as voluntary, or the skeletal muscles described as running on their own.
  • Sympathetic and parasympathetic reversed: the sympathetic branch described as slowing the heart, or "rest and digest" attached to the wrong branch.
  • A muscle pair read as both contracting: the antagonist said to shorten while the agonist shortens, or a flexor credited with straightening a joint.
  • A muscle matched by where it is rather than what it does: the hamstrings chosen for "straighten the knee" because both the question and the answer say "thigh".
  • A gonadal hormone on the wrong gonad: testosterone assigned to the ovaries, or estrogen to the testes.
  • The skin's layers out of order: blood vessels put in the epidermis, or the hypodermis put outside the dermis.
  • The two skin glands exchanged: oil credited to the sweat glands, or sweat credited with waterproofing the skin.
  • A hormone given the other hormone's direction: insulin and glucagon swapped, calcitonin and parathyroid hormone swapped, or ADH said to make the kidneys release water.
  • A gland given another gland's hormone: cortisol named for the thyroid, or insulin named for the pituitary — the question names the gland, and the gland's row in Table 30 is the answer.
  • Negative feedback read as a switch that stays on: the gland said to keep releasing after the level is back to normal, instead of slowing or stopping.
  • The urinary pair swapped: the ureter said to leave the body, or the urethra said to carry urine from the kidney. From the kidney → ureter; out of the body → urethra.
  • The kidney's jobs confused: reabsorption credited with moving waste out, or secretion credited with keeping water. Water kept is reabsorption; waste moved in is secretion.
  • The immune layers flattened: the innate response credited with memory, or a barrier credited with targeting one antigen — the specific, remembering response is the adaptive one.
  • The lymphatic pair swapped: the spleen said to filter lymph, or a lymph node said to filter blood. Lymph nodes filter lymph; the spleen filters blood.
  • The white cells swapped: antibodies credited to the phagocytes, or engulfing credited to the B cells. Phagocytes engulf; B cells make antibodies.
  • A skeletal bone in the wrong division: the ribs or the vertebrae placed in the appendicular skeleton because they are not in a limb's name.
  • A bone's inside and outside reversed: the marrow said to be the hard outer layer, or the compact bone said to make blood cells. Compact bone is outside and dense; red marrow makes blood cells.
  • A joint named by where it is rather than how it moves: the knee called a ball-and-socket, or the shoulder called a hinge.
  • Ligaments and tendons exchanged: a ligament said to join muscle to bone, or a tendon said to join bone to bone.

How to practice this

  • Work the free Human anatomy and physiology practice set with a pencil, and write the path out each time a pathway item appears. Each option is a version of the same list, and writing the order is faster than reading each one.
  • Drill the procedures you get wrong, not the ones you already know. Sorting your errors by procedure beats counting them.
  • Read the explanation on every practice item, including the ones you got right. A right answer reached with the wrong reason comes back on test day.
  • Re-attempt what you missed a day later, not immediately: a day later measures whether the fact stuck.

Where to go next

This topic sits inside the Science section and carries ATI's published 12% of the exam and 18 of the section's 44 scored items — the blueprint's own split.

Source: ATI TEAS Content Specifications — the Science section (50 items: 44 scored + 6 unscored, 60 minutes) and the 'Human anatomy and physiology' sub-content area (12%, 18 scored); every anatomy and physiology fact sourced to OpenStax Anatomy and Physiology 2e (2022, CC BY 4.0) and cross-checked against MedlinePlus, NHLBI, NIDDK, NINDS and NIAMS (ATI accessed 2026-10-07; OpenStax Anatomy and Physiology 2e (2022) accessed 2026-10-08)

See what the TEAS Full Access Pass covers — including the flashcard decks built from the guides